| http://purl.uniprot.org/citations/8621389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8621389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8621389 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen-activated protein/ERK kinase kinases (MEKKs) phosphorylate and activate protein kinases which in turn phosphorylate and activate the p42/44 mitogen-activated protein kinase (MAPK), c-Jun/stress-activated protein kinases (JNKs), and p38/Hog1 kinase. We have isolated the cDNAs for two novel mammalian MEKKs (MEKK 2 and 3). MEKK 2 and 3 encode proteins of 69.7 and 71 kDa, respectively. The kinase domains encoded in the COOH-terminal moiety are 94% conserved; the NH2-terminal moieties are approximately 65% homologous, suggesting this region may encode sequences conferring differential regulation of the two kinases. Expression of MEKK 2 or 3 in HEK293 cells results in activation of p42/44MAPK and JNK but not of p38/Hog1 kinase. Immunoprecipitated MEKK 2 phosphorylated the MAP kinase kinases, MEK 1, and JNK kinase. Titration of MEKK 2 and 3 expression in transfection assays indicated that MEKK 2 preferentially activated JNK while MEKK 3 preferentially activated p42/44MAPK. These findings define a family of MEKK proteins capable of regulating sequential protein kinase pathways involving MAPK members."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.10.5361"xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.10.5361"xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Sather S."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Sather S."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Blank J.L."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Blank J.L."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Johnson G.L."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Johnson G.L."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Elliott E.M."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Elliott E.M."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Gerwins P."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/author | "Gerwins P."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/pages | "5361-5368"xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/pages | "5361-5368"xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/title | "Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/title | "Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase."xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/volume | "271"xsd:string |
| http://purl.uniprot.org/citations/8621389 | http://purl.uniprot.org/core/volume | "271"xsd:string |