| http://purl.uniprot.org/citations/8622651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8622651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8622651 | http://www.w3.org/2000/01/rdf-schema#comment | "Activin exerts its effects by simultaneously binding to two types of p rotein serine/threonine kinase receptors, each type existing in various isoforms. Using the ActR-IB and ActR-IIB receptor isoforms, we have investigated the mechanism of activin receptor activation. ActR-IIB are phosphoproteins with demonstrable affinity for each other. However, activin addition strongly promotes an interaction between these two proteins. Activin binds directly to ActR-IIB, and this complex associates with ActR-IB, which does not bind ligand on its own. In the resulting complex, ActR-IB becomes hyperphosphorylated, and this requires the kinase activity of ActR-IIB. Mutation of conserved serines and threonines in the GS domain, a region just upstream of the kinase domain in ActR-IB, abrogates both phosphorylation and signal propagation, suggesting that this domain contains phosphorylation sites required for signalling. ActR-IB activation can be mimicked by mutation of Thr-206 to aspartic acid, which yields a construct, ActR-IB(T206D), that signals in the absence of ligand. Furthermore, the signalling activity of this mutant construct is undisturbed by overexpression of a dominant negative kinase-defective ActR-IIB construct, indicating that ActR-IB(T206D) can signal independently of ActR-IIB. The evidence suggests that ActR-IIB acts as a primary activin receptor and ActR-IB acts as a downstream transducer of activin signals."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.16.3.1066"xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.16.3.1066"xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/author | "Attisano L."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/author | "Attisano L."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/author | "Massague J."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/author | "Massague J."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/author | "Montalvo E."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/author | "Montalvo E."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/pages | "1066-1073"xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/pages | "1066-1073"xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/title | "Activation of signalling by the activin receptor complex."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/title | "Activation of signalling by the activin receptor complex."xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/8622651 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8622651 |
| http://purl.uniprot.org/citations/8622651 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8622651 |