| http://purl.uniprot.org/citations/8622699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8622699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8622699 | http://www.w3.org/2000/01/rdf-schema#comment | "We have used suppressor genetics to identify factors that interact with Saccharomyces cerevisiae U1 small nuclear RNA (snRNA). In this way, we isolated PRP40-1, a suppressor that restores growth at 18 degrees C to a strain bearing a cold-sensitive mutation in U1 RNA. A gene disruption experiment shows that PRP40 is an essential gene. To study the role of PRP40 in splicing, we created a pool of temperature-sensitive prp40 strains. Primer extension analysis of intron-containing transcripts in prp40 temperature-sensitive strains reveals a splicing defect, indicating that Prp40 plays a direct role in pre-mRNA splicing. In addition, U1 RNA coimmunoprecipitates with Pro40, indicating that Prp40 is bound to the U1 small nuclear ribonucleoprotein particle in vivo. Therefore, we conclude that PRP40 encodes a novel, essential splicing component that associates with the yeast U1 small nuclear ribonucleoprotein particle."xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.16.3.960"xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.16.3.960"xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/author | "Kao H.-Y."xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/author | "Kao H.-Y."xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/author | "Siliciano P.G."xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/author | "Siliciano P.G."xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/pages | "960-967"xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/pages | "960-967"xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/title | "Identification of Prp40, a novel essential yeast splicing factor associated with the U1 small nuclear ribonucleoprotein particle."xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/title | "Identification of Prp40, a novel essential yeast splicing factor associated with the U1 small nuclear ribonucleoprotein particle."xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/8622699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8622699 |
| http://purl.uniprot.org/citations/8622699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8622699 |
| http://purl.uniprot.org/citations/8622699 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8622699 |
| http://purl.uniprot.org/citations/8622699 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8622699 |
| http://purl.uniprot.org/uniprot/P33203 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8622699 |
| http://purl.uniprot.org/uniprot/P33203#attribution-6F5BF1EC0C270CC84A1BCE9C36CC1CF4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8622699 |