| http://purl.uniprot.org/citations/8622770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8622770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8622770 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional silencing of the HM mating-type loci in the yeast Saccharomyces cerevisiae is caused by the localized formation of an altered chromatin structure, analogous to heterochromatin in higher eukaryotes. Silencing depends on cis-acting sequences, termed silencers, as well as several trans-acting factors, including histones H4 and H3, proteins RAP1 and ABF1, and the four SIR proteins (SIR1-4). Each of the four HM silencers contains an autonomously replicating sequence (ARS) to which the origin replication complex (ORC) binds. This six-protein complex is required for initiation of DNA replication, as well as for silencing. Efficient establishment of the silenced state requires both passage through the S phase of the cell cycle and SIR1 protein. Previous experiments suggested that SIR1 might be localized to the silencers by binding to ORC and/or RAP1. Here we report that SIR1 can bind directly to ORC1, the largest of the ORC subunits, and that targeting of SIR1 to ORC1 at a silencer is sufficient to establish a silenced state."xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.org/dc/terms/identifier | "doi:10.1038/381251a0"xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.org/dc/terms/identifier | "doi:10.1038/381251a0"xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/author | "Sternglanz R."xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/author | "Sternglanz R."xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/author | "Triolo T."xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/author | "Triolo T."xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/pages | "251-253"xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/pages | "251-253"xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/title | "Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing."xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/title | "Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing."xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/volume | "381"xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://purl.uniprot.org/core/volume | "381"xsd:string |
| http://purl.uniprot.org/citations/8622770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8622770 |
| http://purl.uniprot.org/citations/8622770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8622770 |
| http://purl.uniprot.org/citations/8622770 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8622770 |
| http://purl.uniprot.org/citations/8622770 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8622770 |
| http://purl.uniprot.org/uniprot/P21691 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8622770 |
| http://purl.uniprot.org/uniprot/P21691#attribution-13FA4E24BA934510CDB1BDD56C478D8A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8622770 |