| http://purl.uniprot.org/citations/8622888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8622888 | http://www.w3.org/2000/01/rdf-schema#comment | "Heregulins (HRGs) induce tyrosine phosphorylation of several members of the erb-B family of receptors. Although originally isolated as the ligands for p185c-erb-2, recent evidence suggests that other receptors of the erbB family, including p180erbB-3 and p180erbB-4, are their true cognate receptors. Stimulation of MDA MB-453 cells with HRG beta 2 resulted in the tyrosine phosphorylation of p185c-erbB-2 and p180erbB-4 in a time- and dose-dependent fashion. This event was accompanied by the formation of multimeric complexes between the activated receptors and SH2-containing proteins. Ligand caused p120-rasGTPase activating protein (GAP), SHC and the p85 subunit of phosphatidylinositol-3'-kinase (PI3K) to be associated with both p185c-erbB-2 and p180erbB-4. In addition, tyrosine phosphorylation of p85-PI3K and SHC, but not of GAP or of its associated p62 and p190 proteins, was also detected. HRG also induced the association of GRB2 with tyrosine phosphorylated p185c-erbB-2, p180erbB-4 and SHC. Activation of mitogen-activated protein kinase (MAPK) ( > 30-fold over untreated controls) was observed upon receptor(s) activation, as it was the induction of the immediate early gene c-fos ( > 200-fold). These observations suggest that p21ras activation plays a role in the HRG pathway. Furthermore, comparative analysis of the binding of p85-PI3K to 185c-erbB-2 and p180erbB-4, revealed a preferential association with activated p180erbB-4. These findings might suggest a model of HRG action in which the relative expression of the various erb-B family members and the partitioning of signal transduction molecules between each type of receptor might determine the nature of the signal elicited by the ligand and the biological response attained."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/author | "Ma Z."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/author | "Cho C."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/author | "Serve H."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/author | "Rosen N."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/author | "Sepp-Lorenzino L."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/author | "Eberhard I."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/author | "Lupu R."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/pages | "1679-1687"xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/title | "Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/8622888 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8622888 |
| http://purl.uniprot.org/citations/8622888 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8622888 |
| http://purl.uniprot.org/uniprot/#_P56975-mappedCitation-8622888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8622888 |
| http://purl.uniprot.org/uniprot/#_Q07889-mappedCitation-8622888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8622888 |
| http://purl.uniprot.org/uniprot/#_P01116-mappedCitation-8622888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8622888 |
| http://purl.uniprot.org/uniprot/#_Q15303-mappedCitation-8622888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8622888 |
| http://purl.uniprot.org/uniprot/#_O14944-mappedCitation-8622888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8622888 |
| http://purl.uniprot.org/uniprot/#_O14511-mappedCitation-8622888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8622888 |
| http://purl.uniprot.org/uniprot/#_P01111-mappedCitation-8622888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8622888 |
| http://purl.uniprot.org/uniprot/#_P01112-mappedCitation-8622888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8622888 |