| http://purl.uniprot.org/citations/8625410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8625410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8625410 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on the presence of the G protein-binding domain. Cellular expression of epitope-tagged WASP produces clusters of WASP that are highly enriched in polymerized actin. This clustering is not observed with a C-terminally deleted WASP and is inhibited by coexpression with dominant negative CDC42Hs-N17, but not with dominant negative forms of Rac or Rho. Thus, WASP provides a novel link between CDC42Hs and the actin cytoskeleton, which suggests a molecular mechanism for many of the cellular abnormalities in WAS. The WASP sequence contains two novel domains that are homologous to other proteins involved in action organization."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81050-8"xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81050-8"xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Francke U."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Francke U."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Karlak B."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Karlak B."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Derry J.M."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Derry J.M."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Abo A."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Abo A."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Lemahieu V."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Lemahieu V."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Symons M."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Symons M."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Mccormick F."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/author | "Mccormick F."xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8625410 | http://purl.uniprot.org/core/name | "Cell"xsd:string |