| http://purl.uniprot.org/citations/8626469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8626469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8626469 | http://www.w3.org/2000/01/rdf-schema#comment | "The HDF1 protein of Saccharomyces cerevisiae shares biochemical properties and structural homology with the 70-kDa subunit of the human autoantigen Ku. The Ku protein, a heterodimer composed of a 70-kDa subunit and an 80-kDa subunit, has been identified as the regulatory subunit of the DNA-dependent protein kinase. This enzyme has recently been shown to be involved in DNA repair and recombination processes in mammalian cells. Here we show that hdf1-disrupted S. cerevisiae strains are strongly sensitive toward the radiomimetic antibiotic bleomycin. In addition, mating-type switching and rates of spontaneous mitotic recombination are strongly reduced. This phenotype is similar to that of mammalian cells lacking components of the DNA-dependent protein kinase holoenzyme, suggesting that HDF1 participates in and exerts equivalent functions in S. cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.14.7910"xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.14.7910"xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/author | "Feldmann H.M."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/author | "Feldmann H.M."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/author | "Mages G.J."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/author | "Mages G.J."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/author | "Winnacker E.-L."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/author | "Winnacker E.-L."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/pages | "7910-7915"xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/pages | "7910-7915"xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/title | "Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/title | "Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination."xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/volume | "271"xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://purl.uniprot.org/core/volume | "271"xsd:string |
| http://purl.uniprot.org/citations/8626469 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8626469 |
| http://purl.uniprot.org/citations/8626469 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8626469 |
| http://purl.uniprot.org/citations/8626469 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8626469 |
| http://purl.uniprot.org/citations/8626469 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8626469 |