| http://purl.uniprot.org/citations/8631303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8631303 | http://www.w3.org/2000/01/rdf-schema#comment | "The Tpl-2 protein serine/threonine kinase was originally identified, in a C-terminally deleted form, as the product of an oncogene associated with the progression of Moloney murine leukemia virus-induced T cell lymphomas in rats. The kinase domain of Tpl-2 is homologous to the Saccharomyces cerevisiae gene product, STE11, which encodes a MAP kinase kinase kinase. This suggested that Tpl-2 might have a similar activity. Consistent with this hypothesis, immunoprecipitated Tpl-2 and Tpl-2deltaC (a C-terminally truncated mutant) phosphorylated and activated recombinant fusion proteins of the mammalian MAP kinase kinases, MEK-1 and SEK-1, in vitro. Furthermore, transfection of Tpl-2 into COS-1 cells or Jurkat T cells. markedly activated the MAP kinases, ERK-1 and SAP kinase (JNK), which are substrates for MEK-1 and SEK-1, respectively. Tpl-2, therefore, is a MAP kinase kinase kinase which can activate two MAP kinase pathways. After Raf and Mos, Tpl-2 is the third serine/threonine oncoprotein kinase that has been shown to function as a direct activator of MEK-1."xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1996.tb00417.x"xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/author | "Carlile G.W."xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/author | "Ley S.C."xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/author | "Pappin D."xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/author | "Salmeron A."xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/author | "Narsimhan R.P."xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/author | "Ahmad T.B."xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/pages | "817-826"xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/title | "Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase."xsd:string |
| http://purl.uniprot.org/citations/8631303 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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