| http://purl.uniprot.org/citations/8633082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8633082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8633082 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rev protein of HIV-1 is essential for the nuclear export of incompletely spliced viral mRNAs. This action depends on the mutationally defined Rev activation domain, which both binds the nucleoporin-like human cellular cofactor Rab/hRIP and also functions as a nuclear export signal. Protein kinase inhibitor alpha (PKI) also contains a potent nuclear export signal. However, PKI plays no role in nuclear RNA export and instead induces the nuclear export of a specific protein target, the catalytic subunit of cAMP-dependent protein kinase. Here, it is demonstrated that the nuclear export signal of PKI not only binds the Rab/hRIP cofactor specifically but also can effectively substitute for the Rev activation domain in mediating the nuclear export of HIV-1 mRNAs. We conclude that HIV-1 Rev and PKI act through an identical nuclear export pathway and that Rev, rather than using a dedicated RNA export pathway, is instead acting as an adaptor that allows viral mRNAs to access a cellular protein export pathway."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.9.4421"xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.9.4421"xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/author | "Cullen B.R."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/author | "Cullen B.R."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/author | "Bogerd H.P."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/author | "Bogerd H.P."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/author | "Fridell R.A."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/author | "Fridell R.A."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/pages | "4421-4424"xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/pages | "4421-4424"xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/title | "Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/title | "Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway."xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/8633082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8633082 |
| http://purl.uniprot.org/citations/8633082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8633082 |
| http://purl.uniprot.org/citations/8633082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8633082 |
| http://purl.uniprot.org/citations/8633082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8633082 |