| http://purl.uniprot.org/citations/8634152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8634152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8634152 | http://www.w3.org/2000/01/rdf-schema#comment | "We have cloned and sequenced the mouse AHD3 cDNA, which codes for the Class 3 microsomal aldehyde dehydrogenase (ALDH3m). The cDNA is 2,997 bp in length excluding the poly(A)+ tail, and has 5' and 3' non-translated regions of 113 bp and 1,429 bp, respectively. The deduced amino acid sequence consists of 484 amino acids, including the first methionine (Mr = 53,942), and contains a hydrophobic segment at the carboxyl terminus which is the putative membrane anchor. The mouse AHD3 protein was found to be: 95% similar to the rat microsomal ALDH3m protein, 65% identical to the mouse, rat and human cytosolic ALDH3c protein, and <28% similar to the rat Class 1 and Class 2 ALDH and methylmalonate-semialdehyde dehydrogenase proteins. Southern hybridization analysis of mouse cDNA probed with the full-length AHD3 cDNA revealed that the Ahd3 gene likely spans less than a total of 25 kb. The mouse Ahd3 gene is very tightly linked to the Ahd4 gene on chromosome 11. Mouse AHD3 mRNA levels are increased by dioxin in mouse Hepa-1c1c7 hepatoma wild-type (wt) cells but not in the Ah receptor nuclear translocator (ARNT)-defective (c4) mutant line, indicating that the induction process is mediated by the Ah (aromatic hydrocarbon) dioxin-binding receptor. AHD3 mRNA levels are also inducible by clofibrate in both the wt and c4 lines. AHD3 mRNA levels are not elevated in the CYP1A1 metabolism-deficient c37 mutant line or as part of the oxidative stress response found in the untreated 14CoS/14CoS mouse cell line. These data indicate that, although inducible by dioxin, the Ahd3 gene does not qualify as a member of the aromatic hydrocarbon [Ah] gene battery."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.org/dc/terms/identifier | "doi:10.1089/dna.1996.15.235"xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.org/dc/terms/identifier | "doi:10.1089/dna.1996.15.235"xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/author | "Nebert D.W."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/author | "Nebert D.W."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/author | "Lindahl R."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/author | "Lindahl R."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/author | "Vasiliou V."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/author | "Vasiliou V."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/name | "DNA Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/name | "DNA Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/pages | "235-245"xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/pages | "235-245"xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/title | "Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/title | "Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping."xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/8634152 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8634152 |
| http://purl.uniprot.org/citations/8634152 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8634152 |