| http://purl.uniprot.org/citations/8635485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8635485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8635485 | http://www.w3.org/2000/01/rdf-schema#comment | "In the signal transduction of transforming growth factor-beta (TGF-beta), the TGF-beta type II receptor (betaR-II) binds TGF-beta, presents the ligand to type I receptor, and forms a heterodimeric receptor complex that functions as an active signaling receptor. We isolated cDNA clones encoding an isoform of human betaR-II from vascular endothelial cells by RT-PCR. The deduced structure of the isoform designated as betaR-IIb contained a 25-amino-acid residue inserted at the extracellular region. The insert exhibited 73% homology to a similar insertion found in a mouse betaR-II variant. BetaR-IIb mRNA was ubiquitously expressed in all human cell lines examined. BetaR-IIb as well as betaR-II stably expressed in betaR-II deficient DR26 cells acted as a functional receptor transducing signals from TGF-beta for growth inhibition and the transcriptional activation of the plasminogen activator inhibitor-1 promoter. These results indicated that the betaR-IIb expressed in mammalian cells functions indistinguishably from in betaR-II. The potential function of betaR-IIb is discussed."xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.org/dc/terms/identifier | "doi:10.1006/excr.1996.0066"xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.org/dc/terms/identifier | "doi:10.1006/excr.1996.0066"xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/author | "Hirai R."xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/author | "Hirai R."xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/author | "Fijita T."xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/author | "Fijita T."xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/pages | "135-141"xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/pages | "135-141"xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/title | "A human transforming growth factor-beta type II receptor that contains an insertion in the extracellular domain."xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/title | "A human transforming growth factor-beta type II receptor that contains an insertion in the extracellular domain."xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/volume | "223"xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://purl.uniprot.org/core/volume | "223"xsd:string |
| http://purl.uniprot.org/citations/8635485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8635485 |
| http://purl.uniprot.org/citations/8635485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8635485 |
| http://purl.uniprot.org/citations/8635485 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8635485 |
| http://purl.uniprot.org/citations/8635485 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8635485 |
| http://purl.uniprot.org/uniprot/P37173 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8635485 |
| http://purl.uniprot.org/uniprot/P37173#attribution-603295071EBA4BC9FD4F7AB6808502F4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8635485 |