| http://purl.uniprot.org/citations/8637716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8637716 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe the molecular cloning of a cDNA for the alpha chain of the human IL-11 receptor (IL-11R alpha) and demonstrate the requirement of either the human or mouse gp130 molecule for signalling. cDNA clones encoding IL-11R alpha were isolated from a bone marrow cDNA library using a fragment from the murine IL-11R alpha as a probe. The human receptor was predicted to consist of 422 amino acids and was found to share 84% identity with the murine protein. In the extra-cellular region it exhibited a single hemopoietin domain with conserved cysteine residues and WSTWS motif. The transmembrane region was followed by a short cytoplasmic tail which did not contain a tyrosine kinase domain. Interaction of the human IL-11R alpha with murine gp130 was demonstrated: expression of the human IL-11R alpha in murine M1 cells which constitutively express murine gp130 (and murine LIF receptor), resulted in the generation of specific high-affinity binding sites for IL-11 (Kd = 250 pM). In addition, expression of the human IL-11R alpha in these cells permitted the induction of macrophage differentiation in response to IL-11. These results suggested that the human IL-11R alpha chain was able to form a functional receptor complex in association with murine gp130. The requirement of gp130 for signalling was confirmed by expression of the human IL-11R alpha in Ba/F3 cells. BaF3 cells that expressed the human IL-11R alpha alone showed binding of radiolabelled IL-11 but no proliferative response. Introduction of human gp130 into these cells resulted in high-affinity IL-11 binding sites and IL-11 dependent cellular proliferation. Thus these results demonstrated the absolute requirement of gp130 for signalling."xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/author | "Hilton D.J."xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/author | "Willson T."xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/author | "Nandurkar H.H."xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/author | "Nathan P."xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/author | "Begley C.G."xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/author | "Nicola N."xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/pages | "585-593"xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/title | "The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor."xsd:string |
| http://purl.uniprot.org/citations/8637716 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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