| http://purl.uniprot.org/citations/8637721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8637721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8637721 | http://www.w3.org/2000/01/rdf-schema#comment | "JNK/SAPKs are identified as new members of the MAPK family; they phosphorylate c-Jun protein in response to several cellular stimuli including ultraviolet irradiation, TNF and osmotic shock. We have identified a protein kinase, MUK, as an activator of the JNK-pathway, whose kinase domain shows significant homology to MAPKKK-related proteins such as c-Raf and MEKK. The over-expression of MUK or MEK kinase (MEKK) in NIH3T3 or COS1 cells results in the activation of JNK1 and the accumulation of a hyper-phosphorylated form of c-Jun. While MEKK also activates the ERK pathway, MUK is a rather selective activator of the JNK pathway. On the other hand, c-Raf activates the JNK pathway only slightly despite its remarkable ability to activate the ERK pathway. Even though we originally identified MUK as a MAPKKK-related protein kinase, a greater similarity to mixed lineage kinase (MLK) is found not only in the catalytic domain but also in the 'leucine-zipper'-like motifs located at the C-terminal side of the catalytic domain. The structural divergence between MUK and MEKK reveals the multiplicity of signaling pathways that activate JNK/SAPKs."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Ohno S."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Ohno S."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Hirai S."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Hirai S."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Izawa M."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Izawa M."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Osada S."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Osada S."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Spyrou G."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/author | "Spyrou G."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/pages | "641-650"xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/pages | "641-650"xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/title | "Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/title | "Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK."xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/8637721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8637721 |
| http://purl.uniprot.org/citations/8637721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8637721 |