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http://purl.uniprot.org/citations/8638164http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8638164http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8638164http://www.w3.org/2000/01/rdf-schema#comment"Transforming growth factor-beta (TGF-beta) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-beta superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-beta, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-beta signal transduction."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.org/dc/terms/identifier"doi:10.1126/science.272.5265.1179"xsd:string
http://purl.uniprot.org/citations/8638164http://purl.org/dc/terms/identifier"doi:10.1126/science.272.5265.1179"xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Gotoh Y."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Gotoh Y."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Irie K."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Irie K."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Matsumoto K."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Matsumoto K."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Yamaguchi K."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Yamaguchi K."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Ueno N."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Ueno N."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Shirakabe K."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Shirakabe K."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Nishida E."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Nishida E."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Shibuya H."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Shibuya H."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Tonegawa A."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/author"Tonegawa A."xsd:string
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8638164http://purl.uniprot.org/core/date"1996"xsd:gYear