| http://purl.uniprot.org/citations/8641286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8641286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8641286 | http://www.w3.org/2000/01/rdf-schema#comment | "The small GTP binding protein Rho is implicated in cytoskeletal responses to extracellular signals such as lysophosphatidic acid to form stress fibers and focal contacts. Here we have purified a Rho-interacting protein with a molecular mass of approximately 164 kDa (p164) from bovine brain. This protein bound to GTPgammaS (a non-hydrolyzable GTP analog).RhoA but not to GDP.RhoA or GTPgammaS.RhoA with a mutation in the effector domain (RhoAA37).p164 had a kinase activity which was specifically stimulated by GTPgammaS.RhoA. We obtained the cDNA encoding p164 on the basis of its partial amino acid sequences and named it Rho-associated kinase (Rho-kinase). Rho-kinase has a catalytic domain in the N-terminal portion, a coiled coil domain in the middle portion and a zinc finger-like motif in the C-terminal portion. The catalytic domain shares 72% sequence homology with that of myotonic dystrophy kinase and the coiled coil domain contains a Rho-interacting interface. When COS7 cells were cotransfected with Rho-kinase and activated RhoA, some Rho-kinase was recruited to membranes. Thus it is likely that Rho-kinase is a putative target serine/threonine kinase for Rho and serves as a mediator of the Rho-dependent signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1996.tb00574.x"xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1996.tb00574.x"xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Amano M."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Amano M."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Iwamatsu A."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Iwamatsu A."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Kaibuchi K."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Kaibuchi K."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Nakano T."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Nakano T."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Matsui T."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Matsui T."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Chihara K."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Chihara K."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Okawa K."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Okawa K."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Nakafuku M."xsd:string |
| http://purl.uniprot.org/citations/8641286 | http://purl.uniprot.org/core/author | "Nakafuku M."xsd:string |