| http://purl.uniprot.org/citations/8641341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8641341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8641341 | http://www.w3.org/2000/01/rdf-schema#comment | "Tyrosine phosphorylation is an early event of interleukin-11 (IL-11)-mediated signal transduction. The IL-11-responsive cell line 3T3-L1 (mouse preadipocytes) was tested for the presence of Src-family protein tyrosine kinases (PTKs). Only p62yes, p59fyn, and p60src were found to be expressed. Immune-complex kinase reactions using the artificial substrate enolase showed that upon stimulation with IL-11, p62yes and p60src were activated, but p59fyn did not appear to be activated. These results correlate with antiphosphotyrosine (APT) immunoblots. IL-11-stimulated cells also revealed increased phosphatidylinositol 3-kinase (PI3K) activity. Increased activity of PI3K was found to be associated with tyrosine phosphorylated proteins and p62yes, after IL-11 treatment. Immunoprecipitation studies with anti-PI3K revealed for the first time that p62yes associated with PI3K in response to IL-11. To summarize, IL-11 activates p60src, p62yes and PI3K but not p59fyn, and this activation of p62yes leads to its association with PI3K and PI3K activation."xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/author | "Yang Y.C."xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/author | "Yang Y.C."xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/author | "Fuhrer D.K."xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/author | "Fuhrer D.K."xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/name | "Exp. Hematol."xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/name | "Exp. Hematol."xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/pages | "195-203"xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/pages | "195-203"xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/title | "Activation of Src-family protein tyrosine kinases and phosphatidylinositol 3-kinase in 3T3-L1 mouse preadipocytes by interleukin-11."xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/title | "Activation of Src-family protein tyrosine kinases and phosphatidylinositol 3-kinase in 3T3-L1 mouse preadipocytes by interleukin-11."xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/8641341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8641341 |
| http://purl.uniprot.org/citations/8641341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8641341 |
| http://purl.uniprot.org/citations/8641341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8641341 |
| http://purl.uniprot.org/citations/8641341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8641341 |
| http://purl.uniprot.org/uniprot/P05480 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8641341 |
| http://purl.uniprot.org/uniprot/P05480#attribution-740D6947A0CDD3D383ADD319C61F6073 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8641341 |
| http://purl.uniprot.org/uniprot/#_P05480-citation-8641341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8641341 |