| http://purl.uniprot.org/citations/8648686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8648686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8648686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8648686 | http://www.w3.org/2000/01/rdf-schema#comment | "Murine gammaherpesvirus 68 (MHV-68) is a naturally occurring virus of murid rodents which displays pathobiological characteristics similar to those of other gammaherpesviruses, including Epstein-Barr virus (EBV). However, unlike EBV and many other gammaherpesviruses, MHV-68 replicates in epithelial cells in vitro and infects laboratory strains of mice and therefore provides a good model for the study of gammaherpesviruses. Studies of sequences around the center of the MHV-68 genome identified a gene (designated BPRF1 for BamHI P fragment rightward open reading frame 1) whose putative product had motifs reminiscent of a transmembrane glycoprotein. All other gammaherpesviruses have a glycoprotein in this genomic position, but the BPRF1 gene showed sequence homology with only the EBV membrane antigen gp340/220. Biochemical analysis showed that the product of BPRF1 was a glycoprotein present on the surface of infected cells, and immunoelectron microscopy showed that it was present in the virus particle. In addition, antibodies to the BPRF1 product raised by using a bacterial fusion protein neutralized the virus in the absence of complement. The predominant molecular weights of the protein were 150,000 and 130,000. Pulse-chase analysis and endoglycosidase-H digestion showed that the 130,000-molecular-weight form was a precursor of the 150,000-molecular-weight form, and cell surface labelling showed that the 150,000-molecular-weight form alone was on the cell surface. We therefore named the protein gp150. Since gp150 is the first virion-associated glycoprotein and neutralizing determinant of MHV-68 to be characterized, it provides a valuable tool for the future study of virus-host interactions."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.70.6.3528-3535.1996"xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.70.6.3528-3535.1996"xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Allen T."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Allen T."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Allen T."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Arrand J.R."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Arrand J.R."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Arrand J.R."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Bennion G."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Bennion G."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Bennion G."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Janjua N.J."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Janjua N.J."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Janjua N.J."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Mackett M."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Mackett M."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Mackett M."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Nash A.A."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Nash A.A."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Nash A.A."xsd:string |
| http://purl.uniprot.org/citations/8648686 | http://purl.uniprot.org/core/author | "Pepper S.D."xsd:string |