| http://purl.uniprot.org/citations/8657284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8657284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8657284 | http://www.w3.org/2000/01/rdf-schema#comment | "Several lines of evidence suggest that both sweet and bitter tastes are transduced via receptors coupled to heterotrimeric guanine-nucleotide-binding proteins (G proteins). Gustducin is a taste receptor cell (TRC)-specific G protein that is closely related to the transducins. Gustducin and rod transducin, which is also expressed in TRCs, have been proposed to couple bitter-responsive receptors to TRC-specific phosphodiesterases to regulate intracellular cyclic nucleotides. Here we investigate gustducin's role in taste transduction by generating and characterizing mice deficient in the gustducin alpha-subunit (alpha-gustducin). As predicted, the mutant mice showed reduced behavioural and electrophysiological responses to bitter compounds, whereas they were indistinguishable from wild-type controls in their responses to salty and sour stimuli. Unexpectedly, mutant mice also exhibited reduced behavioural and electrophysiological responses to sweet compounds. Our results suggest that gustducin is a principal mediator of both bitter and sweet signal transduction."xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.org/dc/terms/identifier | "doi:10.1038/381796a0"xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.org/dc/terms/identifier | "doi:10.1038/381796a0"xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/author | "Margolskee R.F."xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/author | "Margolskee R.F."xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/author | "Gannon K.S."xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/author | "Gannon K.S."xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/author | "Wong G.T."xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/author | "Wong G.T."xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/pages | "796-800"xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/pages | "796-800"xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/title | "Transduction of bitter and sweet taste by gustducin."xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/title | "Transduction of bitter and sweet taste by gustducin."xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/volume | "381"xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://purl.uniprot.org/core/volume | "381"xsd:string |
| http://purl.uniprot.org/citations/8657284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8657284 |
| http://purl.uniprot.org/citations/8657284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8657284 |
| http://purl.uniprot.org/citations/8657284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8657284 |
| http://purl.uniprot.org/citations/8657284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8657284 |