| http://purl.uniprot.org/citations/8663110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8663110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8663110 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokines in the tumor necrosis factor (TNF) family regulate development and function of the immune system. We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag. Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand. Transfected Apo-2L is expressed at the cell surface with its C terminus exposed, indicating a type II transmembrane protein topology. Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure. Soluble Apo-2L induces extensive apoptosis in lymphoid as well as non-lymphoid tumor cell lines. The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors. These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.22.12687"xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.22.12687"xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Ashkenazi A."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Ashkenazi A."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Donahue C.J."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Donahue C.J."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Ruppert S."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Ruppert S."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Moore A."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Moore A."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Marsters S.A."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Marsters S.A."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Pitti R.M."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/author | "Pitti R.M."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/pages | "12687-12690"xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/pages | "12687-12690"xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/title | "Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family."xsd:string |
| http://purl.uniprot.org/citations/8663110 | http://purl.uniprot.org/core/title | "Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family."xsd:string |