| http://purl.uniprot.org/citations/8674117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8674117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8674117 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the expression cloning and characterization of GDNFR-alpha, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF). GDNFR-alpha binds GDNF specifically and mediates activation of the Ret protein-tyrosine kinase (PTK). Treatment of Neuro-2a cells expressing GDNFR-alpha with GDNF rapidly stimulates Ret autophosphorylation. Ret is also activated by treatment with a combination of GDNF and soluble GDNFR-alpha in cells lacking GDNFR-alpha, and this effect is blocked by a soluble Ret-Fc fusion protein. Ret activation by GDNF was also observed in cultured embryonic rat spinal cord motor neurons, a cell type that responds to GDNF in vivo. A model for the stepwise formation of a GDNF signal-transducing complex including GDNF, GDNFR-alpha, and the Ret PTK is proposed."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81311-2"xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81311-2"xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Fang M."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Fang M."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Hu S."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Hu S."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Hu Z."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Hu Z."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Wen D."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Wen D."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Altrock B.W."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Altrock B.W."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Cupples R."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Cupples R."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Jing S."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Jing S."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Antonio L."xsd:string |
| http://purl.uniprot.org/citations/8674117 | http://purl.uniprot.org/core/author | "Antonio L."xsd:string |