| http://purl.uniprot.org/citations/8687483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8687483 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucuronide conjugates of arylamines are thought to be important in the carcinogenic process. This study investigated the pH stability and synthesis of glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites by human and dog liver. Both dog and human liver slices incubated with 0.06 mM [3H]-4-aminobiphenyl produced the N-glucuronide of 4-aminobiphenyl as the major product. After 2 hr of incubation, the N-glucuronide of 4-aminobiphenyl represented 52 and 27% of the total radioactivity recovered by HPLC in dog and human, respectively. When 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, or N-hydroxy-N-acetyl-4-aminobiphenyl was added to human microsomes containing [14C]UDP-glucuronic acid, a new product peak was detected by HPLC. At 0.5 mM, the rate of glucuronidation was N-hydroxy-N-acetyl-4-aminobiphenyl > N-hydroxy-4-aminobiphenyl > 4-aminobiphenyl. The rate of formation of the N-glucuronide of 4-aminobiphenyl was similar to that observed with benzidine and N-acetylbenzidine. The glucuronides of 4-aminobiphenyl and N-hydroxy-4-aminobiphenyl were both acid labile with T1/2 values of 10.5 and 32 min, respectively, at pH 5.5. The glucuronide of N-hydroxy-N-acetyl-4-aminobiphenyl was not acid labile with T1/2 values at pH 5.5 and 7.4 of 55 and 68 min, respectively. The glucuronide of 4-aminobiphenyl was the most acid labile conjugate examined. Thus, the glucuronide of 4-aminobiphenyl is a major product of dog and human liver slice metabolism and likely to play an important role in the carcinogenic process."xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.org/dc/terms/identifier | "doi:10.1016/0006-2952(96)00165-7"xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/author | "Huang G.P."xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/author | "Babu S.R."xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/author | "Davis B.B."xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/author | "Lakshmi V.M."xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/author | "Zenser T.V."xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/name | "Biochem Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/pages | "1679-1685"xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/title | "Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver."xsd:string |
| http://purl.uniprot.org/citations/8687483 | http://purl.uniprot.org/core/volume | "51"xsd:string |
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