| http://purl.uniprot.org/citations/8692271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8692271 | http://www.w3.org/2000/01/rdf-schema#comment | "Elimination of self-reactive B cells must be balanced against the need for B-cell diversity for antibody responses to pathogens. To analyse factors that determine the extent of B-cell negative selection, we crossed CD45-deficient mice with mice carrying immunoglobulin transgenes specific for hen egg lysozyme (HEL). CD45 positively regulates antigen-receptor signalling and CD45-deficient HEL-specific B cells gave diminished signalling in response to HEL. Significantly, few mature CD45-/-B cells accumulated, despite normal immature B-cell production. Circulating HEL autoantigen mediates negative selection of mature CD45+/+ HEL-binding B cells but, in striking contrast, the autoantigen positively selected CD45-/-HEL-binding B cells, promoting their accumulation as long-lived IgD(hi) cells. These findings are consistent with a signal-threshold model for B-cell selection and demonstrate that changes in antigen receptor signalling can cause high-affinity self-reactive B cells to be actively retained instead of eliminated, thus revealing a potential mechanism for inherited susceptibility to autoimmune disease."xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.org/dc/terms/identifier | "doi:10.1038/381325a0"xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/author | "Goodnow C.C."xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/author | "Thomas M.L."xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/author | "Kishihara K."xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/author | "Healy J.I."xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/pages | "325-328"xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/title | "Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45."xsd:string |
| http://purl.uniprot.org/citations/8692271 | http://purl.uniprot.org/core/volume | "381"xsd:string |
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