| http://purl.uniprot.org/citations/8692842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8692842 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription factor IIH (TFIIH) is a multisubunit complex required for transcription and for DNA nucleotide excision repair. TFIIH possesses three enzymatic activities: (i) an ATP-dependent DNA helicase, (ii) a DNA-dependent ATPase, and (iii) a kinase with specificity for the carboxyl-terminal domain of RNA polymerase II. The kinase activity was recently identified as the cdk (cyclin-dependent kinase) activating kinase, CAK, composed of cdk7, cyclin H, and MAT-1. Here we report the isolation and characterization of three distinct CAK-containing complexes from HeLa nuclear extracts: CAK, a novel CAK-ERCC2 complex, and TFIIH. CAK-ERCC2 can efficiently associate with core-TFIIH to reconstitute holo-TFIIH transcription activity. We present evidence proposing a critical role for ERCC2 in mediating the association of CAK with core TFIIH subunits."xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.13.6488"xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/author | "Drapkin R."xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/author | "Cho H."xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/author | "Akoulitchev S."xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/author | "Le Roy G."xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/pages | "6488-6493"xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/title | "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes."xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/8692842 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8692842 |
| http://purl.uniprot.org/citations/8692842 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8692842 |
| http://purl.uniprot.org/uniprot/P51946#attribution-E7F267354820A6B14AA6B97CD2019FF2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8692842 |
| http://purl.uniprot.org/uniprot/P18074#attribution-E7F267354820A6B14AA6B97CD2019FF2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8692842 |
| http://purl.uniprot.org/uniprot/P19447#attribution-E7F267354820A6B14AA6B97CD2019FF2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8692842 |