| http://purl.uniprot.org/citations/8695815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8695815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8695815 | http://www.w3.org/2000/01/rdf-schema#comment | "Translocations involving the IgH locus at chromosomal locus 14q32.3 are a common event in many B-cell malignancies. The translocations, which generally occur into JH and switch regions, are mediated by errors in the two developmentally regulated, lymphocyte-specific pathways: VDJ-and switch-mediated recombination. Dysregulation of cyclin D1 by a t(11;14)(q13;q32) translocation occurs in most cases of mantle-cell lymphoma and in approximately 30% of multiple myeloma (MM) tumors in which a 14q32 translocation can be detected. We show here that in two of three myeloma lines that overexpress cyclin D1, there is an 11;14 translocation into a gamma switch region, suggesting an error in switch recombination. By contrast, 11;14 translocations in mantlecell lymphoma are invariably into or near a JH segment, suggesting an error in VDJ recombination. This is consistent with the fact that myeloma cells have undergone lgH switch recombination, whereas mantle-cell lymphoma cells generally have not."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Smith C.M."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Smith C.M."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Gerhard D.S."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Gerhard D.S."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Bergsagel P.L."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Bergsagel P.L."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Brents L.A."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Brents L.A."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Chesi M."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Chesi M."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Kuehl W.M."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/author | "Kuehl W.M."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/pages | "674-681"xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/pages | "674-681"xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/title | "Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/title | "Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines."xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/8695815 | http://purl.uniprot.org/core/volume | "88"xsd:string |