| http://purl.uniprot.org/citations/8700522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8700522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8700522 | http://www.w3.org/2000/01/rdf-schema#comment | "A number of cyclin/kinase complexes have been identified in mammalian cells that are essential for controlled cell proliferation. Cyclin C was isolated by virtue of its ability to rescue the triple CLN mutation in yeast; however, until now its function has remained unclear. Cyclin C associates with a novel cyclin dependent kinase, CDK8, and we demonstrate that this complex is associated with kinase activity towards the carboxy-terminal domain (CTD) of RNA polymerase II. We have identified at least two distinct cyclin C/CDK8 containing complexes within the cell, a larger complex over 500 kD in size, that also contains the largest subunit of RNA polymerase II, and a smaller 170 kD species. Both of these cyclin C complexes retain potent CTD kinase activity. We further demonstrate that the cyclin C/CDK8 complex associates with the large subunit of RNA polymerase II in vivo, implicating a potential role for cyclin C/CDK8 in regulating its activities."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Shanahan F."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Shanahan F."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Cho H."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Cho H."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Seghezzi W."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Seghezzi W."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Lees E."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Lees E."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Rickert P."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/author | "Rickert P."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/pages | "2631-2640"xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/pages | "2631-2640"xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/title | "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/title | "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II."xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/8700522 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8700522 |
| http://purl.uniprot.org/citations/8700522 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8700522 |