| http://purl.uniprot.org/citations/8710504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8710504 | http://www.w3.org/2000/01/rdf-schema#comment | "The CSRE (carbon source-responsive element) is a sequence motif responsible for the transcriptional activation of gluconeogenic structural genes in Saccharomyces cerevisiae. We have isolated a regulatory gene, DIL1 (derepression of isocitrate lyase, = CAT8), which is specifically required for derepression of CSRE-dependent genes. Expression of CAT8 is carbon source regulated and requires a functional Cat1p (Snf1p) protein kinase. The derepression defect of CAT8 in a cat1 mutant could be suppressed by a mutant Mig1p repressor protein. Derepression of CAT8 also requires a functional HAP2 gene, suggesting a regulatory connection between respiratory and gluconeogenic genes. Carbon source-dependent protein-CSRE complexes detected in a gel retardation analysis with wild-type extracts were absent in cat8 mutant extracts. However, similar experiments with an epitope-tagged CAT8 gene product in the presence of tag-specific antibodies gave evidence against a direct binding of Cat8p to the CSRE. A constitutively expressed GAL4-CAT8 fusion gene revealed a carbon source-dependent transcriptional activation of a UAS(GAL)-containing reporter gene. Activation mediated by Cat8p was no longer detectable in a cat1 mutant. Thus, biosynthetic control of CAT8 as well as transcriptional activation by Cat8p requires a functional Cat1p protein kinase. A model proposing CAT8 as a specific activator of a transcription factor(s) binding to the CSRE is discussed."xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/24.12.2331"xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/author | "Martens E."xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/author | "Rahner A."xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/author | "Scholer A."xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/author | "Schuller H.J."xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/author | "Gollwitzer B."xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/pages | "2331-2337"xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/title | "Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8."xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/8710504 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8710504 |
| http://purl.uniprot.org/citations/8710504 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8710504 |
| http://purl.uniprot.org/uniprot/P39113#attribution-5F98F52B960763FE156E0CA3A8B13244 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8710504 |
| http://purl.uniprot.org/uniprot/P06782#attribution-5F98F52B960763FE156E0CA3A8B13244 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8710504 |
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| http://purl.uniprot.org/uniprot/#_P06782-mappedCitation-8710504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8710504 |
| http://purl.uniprot.org/uniprot/P39113 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8710504 |
| http://purl.uniprot.org/uniprot/P06782 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8710504 |