| http://purl.uniprot.org/citations/8726673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8726673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8726673 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclic guanosine 3',5'-monophosphate (cGMP) levels were determined in retinas from a strain of Labrador Retrievers with inherited retinal dystrophy manifesting at early stages of retinal differentiation. The cGMP contents of dystrophic retinas of dogs from 1 to 4 months of age (n = 7) were significantly higher (p = 0.001) than in age-matched controls of the same breed (n = 11). Ultrastructure along the vertical retinal meridian was studied in developing retinas and findings were related to those of age-matched wild-type controls of the same breed. Slow central to peripheral progression of degeneration was observed in affected dogs. No differences were found in total cGMP-phosphodiesterase (PDE) activity, in PDE subunit composition as determined by Western blotting of 2-month-old homozygote affected retinas, or in the amino acid sequence deduced from the nucleotide sequence of the PDE beta-subunit as compared to controls. This model of photoreceptor degeneration thus is the first case of an apparent abnormality of cGMP metabolism that is not associated with a defect in the PDE catalytic subunits, and it is also the first reported model not associated with severe developmental abnormalities and rapid degeneration."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.org/dc/terms/identifier | "doi:10.1159/000267869"xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.org/dc/terms/identifier | "doi:10.1159/000267869"xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Paulin L."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Paulin L."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Hurwitz M."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Hurwitz M."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Hurwitz R.L."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Hurwitz R.L."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Kommonen B."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Kommonen B."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Kylma T."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Kylma T."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Cohen R.J."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Cohen R.J."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Penn J.S."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/author | "Penn J.S."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/name | "Ophthalmic Res."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/name | "Ophthalmic Res."xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/pages | "19-28"xsd:string |
| http://purl.uniprot.org/citations/8726673 | http://purl.uniprot.org/core/pages | "19-28"xsd:string |