| http://purl.uniprot.org/citations/8752907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8752907 | http://www.w3.org/2000/01/rdf-schema#comment | "The A/WySnJ mouse provides a genetic model for studying new B cell selection into the stable peripheral B cell pool. Unlike the related A/J strain, the A/WySnJ has a single, autosomal codominant gene defect, Bcmd, resulting in a profound peripheral B cell deficiency. Here, continuous in vivo bromodeoxyuridine labeling and immunofluorescence analysis showed normal bone marrow B cell genesis but excessive B cell loss from the marrow and each peripheral pool in A/WySnJ. The A/WySnJ immature B220low/HSAhigh splenic B cell pool was 79% smaller, had a 69% slower renewal rate, and its cells had a 29% shorter average half-life than A/J. The A/WySnJ mature B220high/HSAlow splenic B cell pool was 92% smaller, had an 83% slower renewal rate, and its cells had a 56% shorter average half-life. In reciprocal chimeras, the A/WySnJ marrow failed to repopulate the peripheral B cell pool in A/J mice, whereas the A/J marrow fully reconstituted the A/WySnJ mice. Histochemistry revealed disordered splenic architecture in A/WySnJ, with few primary lymphoid follicles and a second abnormal phenotype, mastocytosis. There was no common genetic basis for B cell deficiency and mastocytosis in the F2 progeny of an (A/WySnJ x CAST/Ei)F1 intercross. We conclude that Bcmd is expressed in bone marrow cells, most likely B cells, where it hinders short-lived B cell maturation to a long-lived phenotype with the potential to form memory B cells."xsd:string |
| http://purl.uniprot.org/citations/8752907 | http://purl.uniprot.org/core/author | "Cancro M.P."xsd:string |
| http://purl.uniprot.org/citations/8752907 | http://purl.uniprot.org/core/author | "Hayes C.E."xsd:string |
| http://purl.uniprot.org/citations/8752907 | http://purl.uniprot.org/core/author | "Lentz V.M."xsd:string |
| http://purl.uniprot.org/citations/8752907 | http://purl.uniprot.org/core/author | "Nashold F.E."xsd:string |
| http://purl.uniprot.org/citations/8752907 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8752907 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/8752907 | http://purl.uniprot.org/core/pages | "598-606"xsd:string |
| http://purl.uniprot.org/citations/8752907 | http://purl.uniprot.org/core/title | "Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse."xsd:string |
| http://purl.uniprot.org/citations/8752907 | http://purl.uniprot.org/core/volume | "157"xsd:string |
| http://purl.uniprot.org/citations/8752907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8752907 |
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