| http://purl.uniprot.org/citations/8755574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8755574 | http://www.w3.org/2000/01/rdf-schema#comment | "The translocation found in acute promyelocytic leukemia rearranges the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor alpha (RARalpha) on chromosome 17. This yields a fusion transcript, PML/RARalpha, a transcription factor with reported dominant negative functions in the absence of hormone. Clinical remissions induced with all-trans retinoic acid (RA) treatment in acute promyelocytic leukemia are linked to PML/RARalpha expression in leukemic cells. To evaluate the PML/RARalpha role in myelopoiesis, transgenic mice expressing PML/RARalpha were engineered. A full-length PML/RARalpha cDNA driven by the CD11b promoter was expressed in transgenic mice. Expression was confirmed in the bone marrow with a reverse transcription PCR assay. Basal total white blood cell and granulocyte counts did not appreciably differ between PML/RARalpha transgenic and control mice. Cell sorter analysis of CD11b+ bone marrow cells revealed similar CD11b+ populations in transgenic and control mice. However, in vitro clonal growth assays performed on peripheral blood from transgenic versus control mice revealed a marked reduction of myeloid progenitors, especially in those responding to granulocyte/ macrophage colony-stimulating factor. Granulocyte/macrophage colony-stimulating factor and kit ligand cotreatment did not overcome this inhibition. Impaired myelopoiesis in vivo was shown by stressing these mice with sublethal irradiation. Following irradiation, PML/RARalpha transgenic mice, as compared with controls, more rapidly depressed peripheral white blood cell and granulocyte counts. As expected, nearly all control mice (94.4%) survived irradiation, yet this irradiation was lethal to 45.8% of PML/RARalpha transgenic mice. Lethality was associated with more severe leukopenia in transgenic versus control mice. Retinoic acid treatment of irradiated PML/RARalpha mice enhanced granulocyte recovery. These data suggest that abnormal myelopoiesis due to PML/RARalpha expression is an early event in oncogenic transformation."xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.15.7900"xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/author | "Martin P."xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/author | "Kakizuka A."xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/author | "Moore M.A."xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/author | "Dmitrovsky E."xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/author | "Nason-Burchenal K."xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/author | "Early E."xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/pages | "7900-7904"xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/title | "Transgenic expression of PML/RARalpha impairs myelopoiesis."xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/8755574 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8755574 |
| http://purl.uniprot.org/citations/8755574 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8755574 |
| http://purl.uniprot.org/uniprot/#_A0A068EW80-mappedCitation-8755574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8755574 |
| http://purl.uniprot.org/uniprot/#_D3YXR5-mappedCitation-8755574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8755574 |
| http://purl.uniprot.org/uniprot/#_F6XUT1-mappedCitation-8755574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8755574 |
| http://purl.uniprot.org/uniprot/#_D3Z2V0-mappedCitation-8755574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8755574 |
| http://purl.uniprot.org/uniprot/#_D3Z3A6-mappedCitation-8755574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8755574 |
| http://purl.uniprot.org/uniprot/#_D6RII9-mappedCitation-8755574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8755574 |
| http://purl.uniprot.org/uniprot/#_F7BTZ2-mappedCitation-8755574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8755574 |
| http://purl.uniprot.org/uniprot/#_F6RQM1-mappedCitation-8755574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8755574 |