| http://purl.uniprot.org/citations/8756328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8756328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8756328 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin-dependent kinase (CDK)-cyclin complexes require phosphorylation on the CDK subunit for full activation of their Ser/Thr protein kinase activity. The crystal structure of the phosphorylated CDK2-CyclinA-ATP gamma S complex has been determined at 2.6 A resolution. The phosphate group, which is on the regulatory T-loop of CDK2, is mostly buried, its charge being neutralized by three Arg side chains. The arginines help extend the influence of the phosphate group through a network of hydrogen bonds to both CDK2 and cyclinA. Comparison with the unphosphorylated CDK2-CyclinA complex shows that the T-loop moves by as much as 7 A, and this affects the putative substrate binding site as well as resulting in additional CDK2-CyclinA contacts. The phosphate group thus acts as a major organizing centre in the CDK2-CyclinA complex."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb0896-696"xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb0896-696"xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/author | "Jeffrey P.D."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/author | "Jeffrey P.D."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/author | "Russo A.A."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/author | "Russo A.A."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/pages | "696-700"xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/pages | "696-700"xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/title | "Structural basis of cyclin-dependent kinase activation by phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/title | "Structural basis of cyclin-dependent kinase activation by phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/8756328 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8756328 |
| http://purl.uniprot.org/citations/8756328 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8756328 |
| http://purl.uniprot.org/citations/8756328 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8756328 |
| http://purl.uniprot.org/citations/8756328 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8756328 |