| http://purl.uniprot.org/citations/8756432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8756432 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel strain of mutant mouse has been generated with a deletion of the gene encoding the NR2C subunit of the NMDA receptor, which is primarily expressed in cerebellar granule cells. Patch-clamp recordings from granule cells in thin cerebellar slices were used to assess the consequences of the gene deletion. In granule cells of wild-type animals, a wide range of single-channel conductances were observed (19-60 pS). The disruption of the NR2C gene results in the disappearance of low-conductance NMDA receptor channels ( < 37 pS) normally expressed in granule cells during developmental maturation. The NMDA receptor-mediated synaptic current is markedly potentiated in amplitude, but abbreviated in duration (with no net difference in total charge), and the non-NMDA component of the synaptic current was reduced. We conclude that the NR2C subunit contributes to functional heteromeric NMDA receptor-subunit assemblies at the mossy fiber synapse and extrasynaptic sites during maturation, and the conductance level exhibited by a given receptor macromolecule may reflect the stochiometry of subunit composition."xsd:string |
| http://purl.uniprot.org/citations/8756432 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.16-16-05014.1996"xsd:string |
| http://purl.uniprot.org/citations/8756432 | http://purl.uniprot.org/core/author | "Tonegawa S."xsd:string |
| http://purl.uniprot.org/citations/8756432 | http://purl.uniprot.org/core/author | "Rossi D.J."xsd:string |
| http://purl.uniprot.org/citations/8756432 | http://purl.uniprot.org/core/author | "Ebralidze A.K."xsd:string |
| http://purl.uniprot.org/citations/8756432 | http://purl.uniprot.org/core/author | "Slater N.T."xsd:string |
| http://purl.uniprot.org/citations/8756432 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8756432 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/8756432 | http://purl.uniprot.org/core/pages | "5014-5025"xsd:string |
| http://purl.uniprot.org/citations/8756432 | http://purl.uniprot.org/core/title | "Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene."xsd:string |
| http://purl.uniprot.org/citations/8756432 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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