http://purl.uniprot.org/citations/8761287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8761287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8761287 | http://www.w3.org/2000/01/rdf-schema#comment | "The prototypic mammalian regulator of cell death is bcl-2, the oncogene implicated in the development of human follicular lymphoma. Several homologues of bcl-2 are now known. Using a PCR-based strategy we cloned a novel member of this gene family, denoted bcl-w. The gene, which is highly conserved between mouse and human, resides near the T-cell antigen receptor alpha gene within the central portion of mouse chromosome 14 and on human chromosome 14 at band q11. Enforced expression of bcl-w rendered lymphoid and myeloid cells refractory to several (but not all) cytotoxic conditions. Thus, like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Comparison of the expected amino acid sequence of Bcl-w with that of these relatives helps to delineate residues likely to convey survival or anti-survival function. While expression of bcl-w was uncommon in B or T lymphoid cell lines, the mRNA was observed in almost all murine myeloid cell lines analysed and in a wide range of tissues. These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Bernard O."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Bernard O."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Adams J.M."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Adams J.M."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Baker E."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Baker E."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Sutherland G.R."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Sutherland G.R."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Huang D.C."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Huang D.C."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Gibson L."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Gibson L."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Cory S."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Cory S."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Holmgreen S.P."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/author | "Holmgreen S.P."xsd:string |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
http://purl.uniprot.org/citations/8761287 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |