| http://purl.uniprot.org/citations/8776664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8776664 | http://www.w3.org/2000/01/rdf-schema#comment | "Spectrin is an actin-binding membrane skeleton protein involved in the maintenance of cell shape and generation of distinct membrane protein domains. Actin binds to the N-terminal domain of beta-spectrin. To examine the function of spectrin-actin interaction in neurons, we sought to disrupt this interaction in differentiating NB 2a neuroblastoma cells by microinjecting an N-terminal domain-specific anti-beta-spectrin antibody. We found that microinjection of the affinity-purified N-terminal domain-specific anti-beta-spectrin inhibited the extension of the neurites in NB 2a/dl cells. The microinjected cells remained flat, and put out many filopodia-like processes; but these processes failed to extend when the cells were induced to differentiate in the presence of dbc AMP or in serum-free medium. The N-terminal domain-specific anti-beta-spectrin also inhibited the binding of spectrin to actin. By contrast, the microinjection of monospecific anti-alpha-spectrin(G) did not inhibit neurite extension. These results suggest that beta-spectrin-actin interaction may be required for neurite extension, which is critical for development of polarity in nerve cells."xsd:string |
| http://purl.uniprot.org/citations/8776664 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1097-4547(19960601)44:5<430::aid-jnr3>3.0.co;2-g"xsd:string |
| http://purl.uniprot.org/citations/8776664 | http://purl.uniprot.org/core/author | "Wang F.S."xsd:string |
| http://purl.uniprot.org/citations/8776664 | http://purl.uniprot.org/core/author | "Sihag R.K."xsd:string |
| http://purl.uniprot.org/citations/8776664 | http://purl.uniprot.org/core/author | "Shea T.B."xsd:string |
| http://purl.uniprot.org/citations/8776664 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8776664 | http://purl.uniprot.org/core/name | "J Neurosci Res"xsd:string |
| http://purl.uniprot.org/citations/8776664 | http://purl.uniprot.org/core/pages | "430-437"xsd:string |
| http://purl.uniprot.org/citations/8776664 | http://purl.uniprot.org/core/title | "Spectrin-actin interaction is required for neurite extension in NB 2a/dl neuroblastoma cells."xsd:string |
| http://purl.uniprot.org/citations/8776664 | http://purl.uniprot.org/core/volume | "44"xsd:string |
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