| http://purl.uniprot.org/citations/8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8787749 | http://www.w3.org/2000/01/rdf-schema#comment | "In Drosophila equalization of the amounts of gene products produced by X-linked genes in the two sexes is achieved by hypertranscription of the single male X chromosome. This process, dosage compensation, is controlled by a set of male-specific lethal (msl) genes, that appear to act at the level of chromatin structure. The properties of the MSL proteins have been extensively studied in the polytene salivary gland chromosomes where they bind to the same set of sites along the male X chromosome in a co-dependent manner. Here we report experiments that show that the MSL proteins first associate with the male X chromosome as early as blastoderm stage, slightly earlier than the histone H4 isoform acetylated at lysine 16 is detected on the X chromosome. MSL binding to the male X chromosome is observed in all somatic tissues of embryos and larvae. Binding of the MSLs to the X chromosome is also interdependent in male embryos and prevented in female embryos by the expression of Sex-lethal (Sxl). A delayed onset of binding of the MSLs in male progeny of homozygous mutant msl-1 or mle mothers coupled with the previous finding that such males have an earlier lethal phase supports the idea that msl-mediated dosage compensation begins early in embryogenesis. Other results show that the maleless (MLE) protein on embryo and larval chromosomes differs in its reactivity with antibodies; the functional significance of this finding remains to be explored."xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.122.9.2751"xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://purl.uniprot.org/core/author | "Franke A."xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://purl.uniprot.org/core/author | "Baker B.S."xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://purl.uniprot.org/core/author | "Dernburg A."xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://purl.uniprot.org/core/author | "Bashaw G.J."xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8787749 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://purl.uniprot.org/core/pages | "2751-2760"xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://purl.uniprot.org/core/title | "Evidence that MSL-mediated dosage compensation in Drosophila begins at blastoderm."xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/8787749 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8787749 |
| http://purl.uniprot.org/citations/8787749 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8787749 |
| http://purl.uniprot.org/uniprot/#_A4V038-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_M9PGK6-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_M9PGW6-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_P50534-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_P50535-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_P50536-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_M9PJB1-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_M9PHB3-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_P84040-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_P19339-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |
| http://purl.uniprot.org/uniprot/#_P24785-mappedCitation-8787749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8787749 |