| http://purl.uniprot.org/citations/8798441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8798441 | http://www.w3.org/2000/01/rdf-schema#comment | "The translocated and normal bcl-2 alleles in the DHL-4 cell line with the t(14;18) translocation were separated by pulsed field electrophoresis. An in vivo footprint over a cAMP response element (CRE) in the bcl-2 5'-flanking sequence was identified on the translocated allele. Electrophoretic mobility shift assays with the bcl-2 CRE demonstrated complexes with mobilities identical to those with a consensus CRE. UV cross-linking experiments revealed that proteins with molecular masses of 34, 43, and 67 kDa bound to the bcl-2 CRE site. Electrophoretic mobility shift assay with an antibody specific to the phosphorylated cAMP response-binding protein (CREB) demonstrated that phosphorylated CREB was present in DHL-4 cells. Treatment with phorbol 12-myristate 13-acetate (PMA) led to an increase in both the amount of phosphorylated CREB and the bcl-2 promoter activity. The response to PMA was dependent on an intact CRE site. The activity of the bcl-2 promoter was increased 20-fold in a construct with the immunoglobulin heavy chain enhancers, and mutation of the CRE site abolished most of the induction. The addition of PMA increased the activity of the bcl-2-immunoglobulin enhancer construct by 3.5-fold. Access to the CRE site is blocked in the silent normal bcl-2 allele, while CREB proteins bind to the site on the translocated allele. We conclude that the CRE site functions as a positive regulatory site for the translocated bcl-2 allele in t(14;18) lymphomas."xsd:string |
| http://purl.uniprot.org/citations/8798441 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.37.22687"xsd:string |
| http://purl.uniprot.org/citations/8798441 | http://purl.uniprot.org/core/author | "Ji L."xsd:string |
| http://purl.uniprot.org/citations/8798441 | http://purl.uniprot.org/core/author | "Mochon E."xsd:string |
| http://purl.uniprot.org/citations/8798441 | http://purl.uniprot.org/core/author | "Boxer L.M."xsd:string |
| http://purl.uniprot.org/citations/8798441 | http://purl.uniprot.org/core/author | "Arcinas M."xsd:string |
| http://purl.uniprot.org/citations/8798441 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8798441 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/8798441 | http://purl.uniprot.org/core/pages | "22687-22691"xsd:string |
| http://purl.uniprot.org/citations/8798441 | http://purl.uniprot.org/core/title | "CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas."xsd:string |
| http://purl.uniprot.org/citations/8798441 | http://purl.uniprot.org/core/volume | "271"xsd:string |
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