| http://purl.uniprot.org/citations/8799135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8799135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8799135 | http://www.w3.org/2000/01/rdf-schema#comment | "A constitutively active form of fibroblast growth factor 2 (FGFR2) was identified in rat osteosarcoma (ROS) cells by an expression cloning strategy. Unlike other tyrosine kinase receptors activated by N-terminal truncation in tumors, this receptor, FGFR2-ROS, contains an altered C terminus generated from chromosomal rearrangement with a novel gene, designated FGFR activating gene 1 (FRAG1). While the removal of the C terminus slightly activates FGFR2, the presence of the FRAG1 sequence drastically stimulates the transforming activity and autophosphorylation of the receptor. FGFR2-ROS is expressed as a unusually large protein and is highly phosphorylated in NIH 3T3 transfectants. FRAG1 is ubiquitously expressed and encodes a predicted protein of 28 kDa lacking significant structural similarity to known proteins. Epitope-tagged FRAG1 protein showed a perinuclear localization by immunofluorescence staining. The highly activated state of FGFR2-ROS appears to be attributed to constitutive dimer formation and higher phosphorylation level as well as possibly altered subcellular localization. These results indicate a unique mechanism of receptor activation by a C terminus alteration through a chromosomal fusion with FRAG1."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.17.8956"xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.17.8956"xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Miki T."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Miki T."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Sakaguchi K."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Sakaguchi K."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Horii Y."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Horii Y."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Yamanaka R."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Yamanaka R."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Lorenzi M.V."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/author | "Lorenzi M.V."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/pages | "8956-8961"xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/pages | "8956-8961"xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/title | "FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/title | "FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement."xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/8799135 | http://purl.uniprot.org/core/volume | "93"xsd:string |