| http://purl.uniprot.org/citations/8799136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8799136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8799136 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoblastoma (RB-1) is a tumor suppressor gene that encodes a 105-kDa nuclear phosphoprotein. To date, RB genes have been isolated only from metazoans. We have isolated a cDNA from maize endosperm whose predicted protein product (ZmRb) shows homology to the "pocket" A and B domains of the Rb protein family. We found ZmRb behaves as a pocket protein based on its ability to specifically interact with oncoproteins encoded by DNA tumor viruses (E7, T-Ag, E1A). ZmRb can interact in vitro and in vivo with the replication-associated protein, RepA, encoded by the wheat dwarf virus. The maize Rb-related protein undergoes changes in level and phosphorylation state concomitant with endoreduplication, and it is phosphorylated in vitro by an S-phase kinase from endoreduplicating endosperm cells. Together, our results suggest that ZmRb is a representative of the pocket protein family and may play a role in cell cycle progression. Moreover, certain plant monopartite geminiviruses may operate similarly to mammalian DNA viruses, by targeting and inactivating the retinoblastoma protein, which otherwise induces G1 arrest."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.17.8962"xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.17.8962"xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "DeCaprio J.A."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "DeCaprio J.A."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Larkins B.A."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Larkins B.A."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Grafi G."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Grafi G."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Helentjaris T."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Helentjaris T."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Burnett R.J."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Burnett R.J."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Kaelin W.G. Jr."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Sellers W.R."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Sellers W.R."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/author | "Kaelin W.G. Jr"xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/pages | "8962-8967"xsd:string |
| http://purl.uniprot.org/citations/8799136 | http://purl.uniprot.org/core/pages | "8962-8967"xsd:string |