| http://purl.uniprot.org/citations/8799178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8799178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8799178 | http://www.w3.org/2000/01/rdf-schema#comment | "We have cloned and expressed a Ca(2+)-activated K+ channel beta-subunit from human brain. The open reading frame encodes a 191-amino acid protein possessing significant homology to a previously described subunit cloned from bovine muscle. The gene for this subunit is located on chromosome 5 at band q34 (hslo-beta). There is no evidence for alternative RNA splicing of this gene product. hslo-beta mRNA is abundantly expressed in smooth muscle, but expression levels are low in most other tissues, including brain. Brain subregions in which beta-subunit mRNA expression is relatively high are the hippocampus and corpus callosum. The coexpression of hslo-beta mRNA together with hslo-alpha subunits in either Xenopus oocytes or stably transfected HEK 293 cells give rise to Ca(2+)-activated potassium currents with a much increased calcium and/or voltage sensitivity. These data indicate that the beta-subunit shows a tissue distribution different to that of the alpha-subunit, and in many tissues there may be no association of alpha-subunits with beta-subunits. These beta-subunits can play a functional role in the regulation of neuronal excitability by tuning the Ca2+ and/or the voltage dependence of alpha-subunits."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.17.9200"xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.17.9200"xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Godinot N."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Godinot N."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Tseng-Crank J."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Tseng-Crank J."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Ahring P.K."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Ahring P.K."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Olesen S.P."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Olesen S.P."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Johansen T.E."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Johansen T.E."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Foster C.D."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Foster C.D."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Mertz R."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Mertz R."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Reinhart P.H."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Reinhart P.H."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Strobaek D."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/author | "Strobaek D."xsd:string |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8799178 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |