| http://purl.uniprot.org/citations/8805280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8805280 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ras/Raf/MEK/MAP kinase cascade transmits signals from activated cell-surface receptors to transcription factors in the nucleus and is an essential component of metazoan intracellular signaling pathways (see, for example, [1-6]). In the mouse, the Raf protein kinase family is comprised of three homologous genes, Raf-1, A-Raf and B-Raf [5] which are ubiquitously expressed in the developing embryo [7]. We have introduced into the mouse germ line a loss-of-function mutation in the X-chromosomal A-Raf gene, by homologous recombination in embryonic stem cells. On a predominantly C57 Bl/6 genetic background, A-Raf-deficient mice displayed neurological and intestinal abnormalities and died between 7 and 21 days post-partum. When the mutated allele was maintained on a predominantly 129/OLA background, by contrast, A-Raf-deficient animals survived to adulthood, did not display obvious intestinal abnormalities, were fertile, but did have a subset of the neurological defects."xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(02)00548-1"xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/author | "McMahon M."xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/author | "Murray R."xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/author | "Pritchard C.A."xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/author | "Slattery R."xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/author | "Bolin L."xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/pages | "614-617"xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/title | "Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene."xsd:string |
| http://purl.uniprot.org/citations/8805280 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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| http://purl.uniprot.org/uniprot/#_B1AUN8-mappedCitation-8805280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8805280 |
| http://purl.uniprot.org/uniprot/#_B1AUP0-mappedCitation-8805280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8805280 |
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