| http://purl.uniprot.org/citations/8805699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8805699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8805699 | http://www.w3.org/2000/01/rdf-schema#comment | "Anterior-posterior (A-P) patterning is of fundamental importance throughout vertebrate embryonic development. Murine members of the trithorax (trx) and Polycomb group (Pc-G) of genes regulate A-P patterning of segmented axial structures, demonstrating conserved upstream regulation of homeotic pathways between Drosophila and mouse. Here we report the positional cloning of a classical mouse mutation, eed (for embryonic ectoderm development), which is the highly conserved homologue of the Drosophila Pc-G gene esc (for extra sex combs), a long-term repressor of homeotic genes. Mutants homozygous for a null allele of eed display disrupted A-P patterning of the primitive streak during gastrulation. Mutant embryos lack a node, notochord and somites, and there is no neural induction. In contrast to absence of anterior structures, extra-embryonic mesoderm is abundant. Mice carrying a hypomorphic eed mutation exhibit posterior transformations along the axial skeleton. These results indicate that eed is required globally for A-P patterning throughout embryogenesis."xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.org/dc/terms/identifier | "doi:10.1038/383250a0"xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.org/dc/terms/identifier | "doi:10.1038/383250a0"xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/author | "Magnuson T."xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/author | "Magnuson T."xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/author | "Faust C."xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/author | "Faust C."xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/author | "Shumacher A."xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/author | "Shumacher A."xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/pages | "250-253"xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/pages | "250-253"xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/title | "Positional cloning of a global regulator of anterior-posterior patterning in mice."xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/title | "Positional cloning of a global regulator of anterior-posterior patterning in mice."xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/volume | "383"xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://purl.uniprot.org/core/volume | "383"xsd:string |
| http://purl.uniprot.org/citations/8805699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8805699 |
| http://purl.uniprot.org/citations/8805699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8805699 |
| http://purl.uniprot.org/citations/8805699 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8805699 |
| http://purl.uniprot.org/citations/8805699 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8805699 |