| http://purl.uniprot.org/citations/8806812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8806812 | http://www.w3.org/2000/01/rdf-schema#comment | "The proto-oncogene c-abl encodes a tyrosine kinase that is hypothesized to function in proliferation-stimulatory signaling pathways. Previous work on mice homozygous for targeted mutations in the c-abl gene (ablml and abl2 mutant strains) has demonstrated multiple defects, including a susceptibility to infections that results in a high mortality rate after weaning. FACS analysis of the hemopoietic system of c-abl mutants demonstrated variable reductions in B and T lymphocytes in adult bone marrow, thymus, spleen, and peripheral blood. In addition, bone marrow from mutants showed a decreased ability to respond to interleukin-7. We further found that B cells from ablm1 mice had a reduced ability to respond to lipopolysaccharide (decreased to 10% of control response) that was dependent on the culture conditions and the tissue of origin of B cells. Peripheral blood from the mutants also had a reduced response to the T cell mitogen concanavalin A. Immune response in ablm1 mice as determined by the mixed lymphocyte response and the sheep red blood cell plaque-forming assay was grossly normal. These findings suggest that although specific signaling pathways in lymphocytes may involve c-Abl, the immune system can function in the absence of a normal c-abl gene product."xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.org/dc/terms/identifier | "doi:10.1006/cimm.1996.0220"xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/author | "Lee G."xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/author | "Goff S.P."xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/author | "Hardin J.D."xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/author | "Boast S."xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/author | "Schwartzberg P.L."xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/author | "Stall A.M."xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/pages | "100-107"xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/title | "Abnormal peripheral lymphocyte function in c-abl mutant mice."xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://purl.uniprot.org/core/volume | "172"xsd:string |
| http://purl.uniprot.org/citations/8806812 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8806812 |
| http://purl.uniprot.org/citations/8806812 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8806812 |
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