| http://purl.uniprot.org/citations/8810321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8810321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8810321 | http://www.w3.org/2000/01/rdf-schema#comment | "We report here the characterization of the human tissue inhibitor of metalloproteinases-2 (TIMP-2) gene. The gene is 83 kilobase pairs (kb) long with exon-intron splicing sites located in preserved positions among the three members of the TIMP family. A 2.6-kb genomic DNA fragment flanking the 5'-end of the gene contains several regulatory elements including five Sp1, two AP-2, one AP-1, and three PEA-3 binding sites. Despite the presence of a complete AP-1 consensus at position -281, the promoter did not respond to 12-O-tetradecanoylphorbol-13-acetate treatment. However, 12-O-tetradecanoylphorbol-13-acetate response was generated by insertion of a similar AP-1 consensus at position -71, indicating the importance of the positioning of this motif. The promoter contains a typical CpG island; however, methylation of this island did not seem to influence gene expression. Analysis of the 3'-end of the gene revealed that the two mRNAs for TIMP-2 (1.2 and 3.8 kb) differ by the selection of their polyadenylation signal sites, but selection of these sites does not affect RNA stability. In summary, the TIMP-2 gene has several features observed in housekeeping genes, and differs significantly from TIMP-1 and TIMP-3 genes. These differences are likely to explain the specific roles that these inhibitors play in the regulation of matrix metalloproteinases."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.41.25498"xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.41.25498"xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8810321 |
| http://purl.uniprot.org/citations/8810321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8810321 |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Schmutte C."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Schmutte C."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Hammani K."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Hammani K."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Bowcock A."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Bowcock A."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Henriet P."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Henriet P."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Blakis A."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Blakis A."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Declerck Y.A."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Declerck Y.A."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Morsette D."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/author | "Morsette D."xsd:string |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8810321 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |