http://purl.uniprot.org/citations/8810328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8810328 | http://www.w3.org/2000/01/rdf-schema#comment | "This study addresses the function of STAT6 in interleukin-4-stimulated gene expression. A specific STAT6 DNA-binding target site has been identified in the promoter of the interleukin-4 receptor gene, and STAT6 is shown to be involved in mediating activation of gene expression via this site. STAT6 can mediate transcription of a heterologous reporter gene construct containing the interleukin-4 receptor STAT6 binding site. In addition, evidence is provided that demonstrates a distinct effect of STAT6 DNA binding specificity on transcriptional regulation since transcription was not stimulated from a competent but different DNA binding site. To confirm the role of STAT6 in gene activation, STAT6 mutant proteins were generated and analyzed for their ability to function in interleukin-4-induced transcription. Although the interleukin-2 gamma chain receptor subunit has been demonstrated to be a component of the interleukin-4 receptor, it is not required for specific gene activation."xsd:string |
http://purl.uniprot.org/citations/8810328 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.41.25555"xsd:string |
http://purl.uniprot.org/citations/8810328 | http://purl.uniprot.org/core/author | "Reich N.C."xsd:string |
http://purl.uniprot.org/citations/8810328 | http://purl.uniprot.org/core/author | "Kotanides H."xsd:string |
http://purl.uniprot.org/citations/8810328 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
http://purl.uniprot.org/citations/8810328 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
http://purl.uniprot.org/citations/8810328 | http://purl.uniprot.org/core/pages | "25555-25561"xsd:string |
http://purl.uniprot.org/citations/8810328 | http://purl.uniprot.org/core/title | "Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene."xsd:string |
http://purl.uniprot.org/citations/8810328 | http://purl.uniprot.org/core/volume | "271"xsd:string |
http://purl.uniprot.org/citations/8810328 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8810328 |
http://purl.uniprot.org/citations/8810328 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8810328 |
http://purl.uniprot.org/uniprot/P42226#attribution-56A9B0F00857BBF135B38EA1BC49BBE1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8810328 |