| http://purl.uniprot.org/citations/8821656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8821656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8821656 | http://www.w3.org/2000/01/rdf-schema#comment | "In budding yeast, one of three G1 cyclins is required for progression though START, when cells commit to a further round of cell division. We have identified mutations in ALG1 (ERC14), a gene required for N-glycosylation, which are inviable in a cln1 cln2 background but are rescued by over-expression of CLNs. CLN1 and CLN2 are much more efficient than CLN3 in rescuing the erc14-1 allele. The erc14-1 allele results in a significant N-glycosylation defect, and no rescue of this defect by CLN1 over-expression was detected. These data suggest that CLN over-expression could be allowing cells to live with lower levels of N-glycosylation, possibly by overcoming a checkpoint sensitive to N-glycosylation capacity. A plasmid suppressor of alg1, PSA1, encodes a 361 amino-acid protein with homology to NDP-hexose pyrophosphorylases, the enzymes that catalyze the formation of activated sugar nucleotides. PSA1 is an essential gene, and PSA1 transcription is nearly co-ordinately regulated with CLN2 transcription, peaking near START. Co-ordinate regulation of glycosylation, sugar nucleotide metabolism, and cell-cycle progression through G1 may be a feature that ensures adequate cell-wall precursors are present before bud emergence."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.org/dc/terms/identifier | "doi:10.1007/s002940050024"xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.org/dc/terms/identifier | "doi:10.1007/s002940050024"xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Roos J."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Roos J."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Lennarz W.J."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Lennarz W.J."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Cross F.R."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Cross F.R."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Benton B.K."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Benton B.K."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Plump S.D."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/author | "Plump S.D."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/name | "Curr. Genet."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/name | "Curr. Genet."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/pages | "106-113"xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/pages | "106-113"xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/title | "Over-expression of S. cerevisiae G1 cyclins restores the viability of alg1 N-glycosylation mutants."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/title | "Over-expression of S. cerevisiae G1 cyclins restores the viability of alg1 N-glycosylation mutants."xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/8821656 | http://purl.uniprot.org/core/volume | "29"xsd:string |