| http://purl.uniprot.org/citations/8827523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8827523 | http://www.w3.org/2000/01/rdf-schema#comment | "The human apolipoprotein (apo) C-IV gene has been recently identified: it is closely linked to the promoter region of the apoC-II gene (Allan, C.M., D. Walker, J. Segrest, and J. M. Taylor. 1995. Genomics. 28: 291-300). To determine the effect of apoC-IV gene expression on lipoprotein metabolism, transgenic mice were generated using a human apoC-IV cDNA construct. Human apoC-IV was found associated with plasma lipoproteins (d < 1.21 g/ml), mainly in very low density lipoproteins (VLDL), and higher molecular mass isoforms were present, due to N-linked glycosylation and variable sialylation of apoC-IV. Human apoC-IV transgenic mice were hypertriglyceridemic compared to nontransgenic controls; the accumulated plasma triglycerides were present mainly in VLDL. There was little change in plasma cholesterol levels, although apoC-IV expression redistributed cholesterol to VLDL and larger particles in low density lipoprotein/large high density lipoprotein fractions. By immunoblot analysis, apoC-IV was not detected in normal adult human plasma or isolated plasma lipoproteins, a finding consistent with our previous observation of very low levels of human apoC-IV mRNA in human liver. However, our analysis of transgenic mice provides unequivocal evidence that human apoC-IV is a lipid-binding protein belonging to the apolipoprotein family and that it has the potential to alter lipoprotein metabolism."xsd:string |
| http://purl.uniprot.org/citations/8827523 | http://purl.uniprot.org/core/author | "Taylor J.M."xsd:string |
| http://purl.uniprot.org/citations/8827523 | http://purl.uniprot.org/core/author | "Allan C.M."xsd:string |
| http://purl.uniprot.org/citations/8827523 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8827523 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/8827523 | http://purl.uniprot.org/core/pages | "1510-1518"xsd:string |
| http://purl.uniprot.org/citations/8827523 | http://purl.uniprot.org/core/title | "Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/8827523 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/8827523 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8827523 |
| http://purl.uniprot.org/citations/8827523 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8827523 |
| http://purl.uniprot.org/uniprot/P55056#attribution-24757F900CB9844E9C5D0351F0FE35EA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8827523 |