| http://purl.uniprot.org/citations/8828496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8828496 | http://www.w3.org/2000/01/rdf-schema#comment | "GH induces phosphorylation of a number of cellular proteins, of which several have now been identified, such as mitogen-activated protein kinase, insulin receptor substrate-1, and members of the JAK kinase and STAT families of proteins. However, other phosphorylated proteins remain unidentified. Growth factors and cytokines, including epidermal growth factor, insulin, pp60v-scr, and angiotensin II, induce a rapid phosphorylation of annexin I, a 35-kDa member of the annexin family of Ca2+ and phospholipid-binding proteins. The osteoblast-like rat osteosarcoma cell-line UMR-106.01, in which GH acts as a mitogen via a high affinity GH receptor, was used as a model for GH-induced protein phosphorylation. It is demonstrated by immunoblotting and immunoprecipitation techniques that GH induces the phosphorylation of annexin I on tyrosine residues. This phosphorylation is dose and time dependent. Induction of annexin I phosphorylation is delayed compared with that of JAK2. These results identify annexin I as a protein that becomes tyrosine phosphorylated under the influence of GH and show that phosphorylation of annexin I is a general phenomenon that follows activation of a cell by hormones or cytokines."xsd:string |
| http://purl.uniprot.org/citations/8828496 | http://purl.org/dc/terms/identifier | "doi:10.1210/endo.137.10.8828496"xsd:string |
| http://purl.uniprot.org/citations/8828496 | http://purl.uniprot.org/core/author | "Salles J.P."xsd:string |
| http://purl.uniprot.org/citations/8828496 | http://purl.uniprot.org/core/author | "Netelenbos J.C."xsd:string |
| http://purl.uniprot.org/citations/8828496 | http://purl.uniprot.org/core/author | "Slootweg M.C."xsd:string |
| http://purl.uniprot.org/citations/8828496 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8828496 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/8828496 | http://purl.uniprot.org/core/pages | "4358-4362"xsd:string |
| http://purl.uniprot.org/citations/8828496 | http://purl.uniprot.org/core/title | "Growth hormone induces tyrosine phosphorylation of annexin I in rat osteosarcoma cells."xsd:string |
| http://purl.uniprot.org/citations/8828496 | http://purl.uniprot.org/core/volume | "137"xsd:string |
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