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http://purl.uniprot.org/citations/8836918http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8836918http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8836918http://www.w3.org/2000/01/rdf-schema#comment"Three variants of human interferon (IFN)-alpha 8a gene, that is, IFN-alpha 8b, and IFN-alpha 8c, have been reported previously. They differ from each other by changes in their coding region at nucleotide positions 359-360, 372, and 550. Human genomic DNA obtained from over 28,000 healthy blood donors and from 4 human cell lines was used in the polymerase chain reaction (PCR) designed for specific amplification of the IFN-alpha 8 gene fragments. The resulting PCR product was analyzed by (1) restriction endonuclease digestion, (2) DNA sequencing, and (3) allele-specific secondary PCR amplification. Only one sequence for IFN-alpha 8 was identified, and that was for IFN-alpha 8b. The sequences for IFN-alpha 8a and IFN-alpha 8c were not detected after PCR amplification either in the pooled leukocytes obtained from > 28,000 individuals or in cell lines tested. These data suggest that the naturally occurring variant or allele for IFN-alpha 8 in the population is IFN-alpha 8b. IFN-alpha 8a and IFN-alpha 8c variants were consistently below the level of detection of the assays and, if present at all in the population, are very rare."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.org/dc/terms/identifier"doi:10.1089/jir.1996.16.523"xsd:string
http://purl.uniprot.org/citations/8836918http://purl.org/dc/terms/identifier"doi:10.1089/jir.1996.16.523"xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/author"Liao M.-J."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/author"Liao M.-J."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/author"Hussain M."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/author"Hussain M."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/author"Gill D.S."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/author"Gill D.S."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/author"Testa D."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/author"Testa D."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/name"J. Interferon Cytokine Res."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/name"J. Interferon Cytokine Res."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/pages"523-529"xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/pages"523-529"xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/title"Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/title"Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population."xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/8836918http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/8836918http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8836918
http://purl.uniprot.org/citations/8836918http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8836918