| http://purl.uniprot.org/citations/8837778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8837778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8837778 | http://www.w3.org/2000/01/rdf-schema#comment | "Many cytokines signal through different cell-surface receptors to activate the transcription factor NF-kappaB. Members of the TRAF protein family have been implicated in the activation of NF-kappaB by the tumour-necrosis factor (TNF)-receptor superfamily. Here we report the identification of a new TRAF family member, designated TRAF6. When overexpressed in human 293 cells, TRAF6 activates NF-kappaB. A dominant-negative mutant of TRAF6 inhibits NF-kappaB activation signalled by interleukin-1 (IL-1) but not by TNF. IL-1 treatment of 293 cells induces the association of TRAF6 with IRAK, a serine/threonine kinase that is rapidly recruited to the IL-1 receptor after IL-1 induction. These findings indicate that TRAF proteins may function as signal transducers for distinct receptor families and that TRAF6 participates in IL-1 signalling."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.org/dc/terms/identifier | "doi:10.1038/383443a0"xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.org/dc/terms/identifier | "doi:10.1038/383443a0"xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Cao Z."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Cao Z."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Takeuchi M."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Takeuchi M."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Xiong J."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Xiong J."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Goeddel D.V."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Goeddel D.V."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Kurama T."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/author | "Kurama T."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/pages | "443-446"xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/pages | "443-446"xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/title | "TRAF6 is a signal transducer for interleukin-1."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/title | "TRAF6 is a signal transducer for interleukin-1."xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/volume | "383"xsd:string |
| http://purl.uniprot.org/citations/8837778 | http://purl.uniprot.org/core/volume | "383"xsd:string |