| http://purl.uniprot.org/citations/8837779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8837779 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of a system to regulate its responsiveness in the presence of a continuous stimulus, often termed desensitization, has been extensively characterized for the beta2-adrenergic receptor (beta2AR). beta2AR signalling is rapidly attenuated through receptor phosphorylation and subsequent binding of the protein beta-arrestin. Ultimately the receptor undergoes internalization, and although the molecular mechanism is unclear, receptor phosphorylation and beta-arrestin binding have been implicated in this processs. Here we report that beta-arrestin and arrestin-3, but not visual arrestin, promote beta2AR internalization and bind with high affinity directly and stoichiometrically to clathrin, the major structural protein of coated pits. Moreover, beta-arrestin/arrestin chimaeras that are defective in either beta2AR or clathrin binding show a reduced ability to promote beta2AR endocytosis. Immunofluorescence microscopy of intact cells indicates an agonist-dependent colocalization of the beta2AR and beta-arrestin with clathrin. These results show that beta-arrestin functions as an adaptor in the receptor-mediated endocytosis pathway, and suggest a general mechanism for regulating the trafficking of G-protein-coupled receptors."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.org/dc/terms/identifier | "doi:10.1038/383447a0"xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/author | "Benovic J.L."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/author | "Gurevich V.V."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/author | "Goodman O.B. Jr."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/author | "Keen J.H."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/author | "Penn R.B."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/author | "Gagnon A.W."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/author | "Krupnick J.G."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/author | "Santini F."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/pages | "447-450"xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/title | "Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor."xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://purl.uniprot.org/core/volume | "383"xsd:string |
| http://purl.uniprot.org/citations/8837779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8837779 |
| http://purl.uniprot.org/citations/8837779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8837779 |
| http://purl.uniprot.org/uniprot/#_P63010-mappedCitation-8837779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8837779 |
| http://purl.uniprot.org/uniprot/#_P25103-mappedCitation-8837779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8837779 |
| http://purl.uniprot.org/uniprot/#_Q0JRZ9-mappedCitation-8837779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8837779 |
| http://purl.uniprot.org/uniprot/#_P07550-mappedCitation-8837779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8837779 |
| http://purl.uniprot.org/uniprot/#_P30518-mappedCitation-8837779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8837779 |
| http://purl.uniprot.org/uniprot/#_P30556-mappedCitation-8837779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8837779 |
| http://purl.uniprot.org/uniprot/#_P32121-mappedCitation-8837779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8837779 |