http://purl.uniprot.org/citations/8838309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8838309 | http://www.w3.org/2000/01/rdf-schema#comment | "The Lps locus on mouse chromosome 4 controls host responsiveness to lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria. The C3H/HeJ inbred mouse strain is characterized by a mutant Lps allel (Lpsd) that renders it hyporesponsive to LPS and naturally tolerant of its lethal effects. To identify the Lps gene by a positional cloning strategy, we have generated a high-resolution linkage map of the chromosomal region surrounding this locus. We have analyzed a total of 1604 backcross mice from a preexisting interspecific backcross panel of 259 (Mus spretus x C57BL/6J)F1 x C57BL/6J and two novel panels of 597 (DBA/2J x C3H/HeJ)F1 x C3H/HeJ and 748 (C57BL/6J x C3H/HeJ)F1 x C3H/HeJ segregating at Lps. A total of 50 DNA markers have been mapped in a 11.8-cM span overlapping the Lps locus. This positions the Lps locus within a 1.1-cM interval, flanked proximally by a large cluster of markers, including three know genes (Cd301, Hxb, and Ambp), and distally by two microsatellite markers (D4Mit7/D4Mit178). The localization of the Lps locus is several centimorgans proximal to that previously assigned."xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.1996.0050"xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/author | "Gros P."xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/author | "Lariviere L."xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/author | "Malo D."xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/author | "Sebastiani G."xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/author | "Skamene E."xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/author | "Clermont S."xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/author | "Qureshi S.T."xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/pages | "283-294"xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/title | "A high-resolution map in the chromosomal region surrounding the Lps locus."xsd:string |
http://purl.uniprot.org/citations/8838309 | http://purl.uniprot.org/core/volume | "31"xsd:string |
http://purl.uniprot.org/citations/8838309 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8838309 |
http://purl.uniprot.org/citations/8838309 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8838309 |
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http://purl.uniprot.org/uniprot/#_Q3UFS3-mappedCitation-8838309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8838309 |
http://purl.uniprot.org/uniprot/#_L0CMZ8-mappedCitation-8838309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8838309 |
http://purl.uniprot.org/uniprot/#_P10518-mappedCitation-8838309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8838309 |